Calcineurin and Sorting-Related Receptor with A-Type Repeats Interact to Regulate the Renal Na(+)-K(+)-2Cl(−) Cotransporter

The furosemide-sensitive Na(+)-K(+)-2Cl(−)-cotransporter (NKCC2) is crucial for NaCl reabsorption in kidney thick ascending limb (TAL) and drives the urine concentrating mechanism. NKCC2 activity is modulated by N-terminal phosphorylation and dephosphorylation. Serine-threonine kinases that activate...

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Dettagli Bibliografici
Pubblicato in:J Am Soc Nephrol
Autori principali: Borschewski, Aljona, Himmerkus, Nina, Boldt, Christin, Blankenstein, Katharina I., McCormick, James A., Lazelle, Rebecca, Willnow, Thomas E., Jankowski, Vera, Plain, Allein, Bleich, Markus, Ellison, David H., Bachmann, Sebastian, Mutig, Kerim
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2016
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4696563/
https://ncbi.nlm.nih.gov/pubmed/25967121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014070728
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