The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension

Calcineurin inhibitors (CNIs) are immunosuppressive drugs, which are used widely to prevent rejection of transplanted organs and treat autoimmune disease. Hypertension and renal tubule dysfunction, including hyperkalemia, hypercalciuria, and acidosis often complicate their use(1,2). These side effec...

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Detalhes bibliográficos
Main Authors: Hoorn, Ewout J., Walsh, Stephen B., McCormick, James A., Fürstenberg, Antje, Yang, Chao-Ling, Roeschel, Tom, Paliege, Alexander, Howie, Alexander J., Conley, James, Bachmann, Sebastian, Unwin, Robert J., Ellison, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192268/
https://ncbi.nlm.nih.gov/pubmed/21963515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2497
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