The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension

Calcineurin inhibitors (CNIs) are immunosuppressive drugs, which are used widely to prevent rejection of transplanted organs and treat autoimmune disease. Hypertension and renal tubule dysfunction, including hyperkalemia, hypercalciuria, and acidosis often complicate their use(1,2). These side effec...

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Autori principali: Hoorn, Ewout J., Walsh, Stephen B., McCormick, James A., Fürstenberg, Antje, Yang, Chao-Ling, Roeschel, Tom, Paliege, Alexander, Howie, Alexander J., Conley, James, Bachmann, Sebastian, Unwin, Robert J., Ellison, David H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192268/
https://ncbi.nlm.nih.gov/pubmed/21963515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2497
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