SPAK Differentially Mediates Vasopressin Effects on Sodium Cotransporters

Activation of the Na(+)-K(+)-2Cl(−)-cotransporter (NKCC2) and the Na(+)-Cl(−)-cotransporter (NCC) by vasopressin includes their phosphorylation at defined, conserved N-terminal threonine and serine residues, but the kinase pathways that mediate this action of vasopressin are not well understood. Two...

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Autori principali: Saritas, Turgay, Borschewski, Aljona, McCormick, James A., Paliege, Alexander, Dathe, Christin, Uchida, Shinichi, Terker, Andrew, Himmerkus, Nina, Bleich, Markus, Demaretz, Sylvie, Laghmani, Kamel, Delpire, Eric, Ellison, David H., Bachmann, Sebastian, Mutig, Kerim
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2013
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582200/
https://ncbi.nlm.nih.gov/pubmed/23393317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012040404
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