A SPAK isoform switch modulates renal salt transport and blood pressure

The renal thick ascending limb (TAL) and distal convoluted tubule (DCT) play central roles in salt homeostasis and blood pressure regulation. An emerging model suggests that bumetanide and thiazide-sensitive NaCl transporters (NKCC2 and NCC) along these segments are phosphorylated and activated by W...

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Main Authors: McCormick, James A., Mutig, Kerim, Nelson, Joshua H., Saritas, Turgay, Hoorn, Ewout J., Yang, Chao-Ling, Rogers, Shaunessy, Curry, Joshua, Delpire, Eric, Bachmann, Sebastian, Ellison, David H.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172576/
https://ncbi.nlm.nih.gov/pubmed/21907141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.07.009
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