Short DNA sequences from the cytoplasm of mouse tumor cells induce immortalization of human lymphocytes in vitro.

Cytoplasts of mouse L929 and Ehrlich ascites tumor cells harbor DNA sequences that induce unlimited proliferation ("immortalization") of human lymphocytes after transfection in vitro. By equilibrium centrifugation of cytoplasmic lysates in a neutral CsCl gradient, the immortalizing activity was reco...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Abken, H, Hegger, R, Bützler, C, Willecke, K
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1993
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46963/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8341663/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.14.6518
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