Roles of palmitoylation and the KIKK membrane-targeting motif in leukemogenesis by oncogenic KRAS4A

BACKGROUND: We have previously shown that palmitoylation is essential for NRAS leukemogenesis, suggesting that targeting RAS palmitoylation may be an effective therapy for NRAS-related cancers. For KRAS-driven cancer, although much research has been focused on the KRAS4B splice variant, which does n...

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Vydáno v:J Hematol Oncol
Hlavní autoři: Zhao, Huanbin, Liu, Ping, Zhang, Ruihong, Wu, Min, Li, Donghe, Zhao, Xuemei, Zhang, Chun, Jiao, Bo, Chen, Bing, Chen, Zhu, Ren, Ruibao
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4696201/
https://ncbi.nlm.nih.gov/pubmed/26715448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-015-0226-1
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