Constitutive expression of AhR and BRCA-1 promoter CpG hypermethylation as biomarkers of ERα-negative breast tumorigenesis

BACKGROUND: Only 5–10 % of breast cancer cases is linked to germline mutations in the BRCA-1 gene and occurs early in life. Conversely, sporadic breast tumors, which represent 90-95 % of breast malignancies, have lower BRCA-1 expression, but not mutated BRCA-1 gene, and tend to occur later in life i...

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Detaylı Bibliyografya
Yayımlandı:BMC Cancer
Asıl Yazarlar: Romagnolo, Donato F., Papoutsis, Andreas J., Laukaitis, Christina, Selmin, Ornella I.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4696163/
https://ncbi.nlm.nih.gov/pubmed/26715507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-2044-9
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