The IMiDs targets IKZF-1/3 and IRF4 as novel negative regulators of NK cell-activating ligands expression in multiple myeloma

Immunomodulatory drugs (IMiDs) have potent anti-tumor activities in multiple myeloma (MM) and are able to enhance the cytotoxic function of natural killer (NK) cells, important effectors of the immune response against MM. Here, we show that these drugs can enhance the expression of the NKG2D and DNA...

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Udgivet i:Oncotarget
Main Authors: Fionda, Cinzia, Abruzzese, Maria Pia, Zingoni, Alessandra, Cecere, Francesca, Vulpis, Elisabetta, Peruzzi, Giovanna, Soriani, Alessandra, Molfetta, Rosa, Paolini, Rossella, Ricciardi, Maria Rosaria, Petrucci, Maria Teresa, Santoni, Angela, Cippitelli, Marco
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695140/
https://ncbi.nlm.nih.gov/pubmed/26269456
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