The homeobox transcription factor MEIS2 is a regulator of cancer cell survival and IMiDs activity in Multiple Myeloma: modulation by Bromodomain and Extra-Terminal (BET) protein inhibitors

The transcription factor Myeloid Ecotropic Insertion Site 2 (MEIS2) has been identified as a cellular substrate of the E3-ubiquitin ligase complex CRL4-cereblon ((CRL4)CRBN) in crystal structure and by biochemical screen. Emerging evidence suggests that IMiDs can block MEIS2 from binding to CRBN fac...

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Gepubliceerd in:Cell Death Dis
Hoofdauteurs: Abruzzese, Maria Pia, Bilotta, Maria Teresa, Fionda, Cinzia, Zingoni, Alessandra, Soriani, Alessandra, Petrucci, Maria Teresa, Ricciardi, Maria Rosaria, Molfetta, Rosa, Paolini, Rossella, Santoni, Angela, Cippitelli, Marco
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459881/
https://ncbi.nlm.nih.gov/pubmed/30975979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1562-9
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