AF4 and AF4-MLL mediate transcriptional elongation of 5-lipoxygenase mRNA by 1, 25-dihydroxyvitamin D(3)

The human 5-lipoxygenase (5-LO), encoded by the ALOX5 gene, is the key enzyme in the formation of pro-inflammatory leukotrienes. ALOX5 gene transcription is strongly stimulated by calcitriol (1α, 25-dihydroxyvitamin D(3)) and TGFβ (transforming growth factor-β). Here, we investigated the influence o...

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Publicat a:Oncotarget
Autors principals: Ahmad, Khalil, Scholz, Bastian, Capelo, Ricardo, Schweighöfer, Ilona, Kahnt, Astrid Stefanie, Marschalek, Rolf, Steinhilber, Dieter
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694866/
https://ncbi.nlm.nih.gov/pubmed/26329759
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