Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors

Foxp3(+) regulatory T cells (Tregs) are often highly enriched within the tumor-infiltrating T cell pool. Using a well-characterised model of carcinogen-induced fibrosarcomas we show that the enriched tumor-infiltrating Treg population comprises largely of CXCR3(+) T-bet(+) ‘T(H)1-like’ Tregs which a...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Colbeck, Emily J., Hindley, James P., Smart, Kathryn, Jones, Emma, Bloom, Anja, Bridgeman, Hayley, McPherson, Rhoanne C., Turner, Darryl G., Ladell, Kristin, Price, David A., O'Connor, Richard A., Anderton, Stephen M., Godkin, Andrew J., Gallimore, Awen M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Priority Immunology Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694785/
https://ncbi.nlm.nih.gov/pubmed/26433463
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