Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors

Foxp3(+) regulatory T cells (Tregs) are often highly enriched within the tumor-infiltrating T cell pool. Using a well-characterised model of carcinogen-induced fibrosarcomas we show that the enriched tumor-infiltrating Treg population comprises largely of CXCR3(+) T-bet(+) ‘T(H)1-like’ Tregs which a...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Colbeck, Emily J., Hindley, James P., Smart, Kathryn, Jones, Emma, Bloom, Anja, Bridgeman, Hayley, McPherson, Rhoanne C., Turner, Darryl G., Ladell, Kristin, Price, David A., O'Connor, Richard A., Anderton, Stephen M., Godkin, Andrew J., Gallimore, Awen M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Priority Immunology Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694785/
https://ncbi.nlm.nih.gov/pubmed/26433463
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