Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors

Foxp3(+) regulatory T cells (Tregs) are often highly enriched within the tumor-infiltrating T cell pool. Using a well-characterised model of carcinogen-induced fibrosarcomas we show that the enriched tumor-infiltrating Treg population comprises largely of CXCR3(+) T-bet(+) ‘T(H)1-like’ Tregs which a...

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Xehetasun bibliografikoak
Argitaratua izan da:Oncotarget
Egile Nagusiak: Colbeck, Emily J., Hindley, James P., Smart, Kathryn, Jones, Emma, Bloom, Anja, Bridgeman, Hayley, McPherson, Rhoanne C., Turner, Darryl G., Ladell, Kristin, Price, David A., O'Connor, Richard A., Anderton, Stephen M., Godkin, Andrew J., Gallimore, Awen M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Impact Journals LLC 2015
Gaiak:
Priority Immunology Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694785/
https://ncbi.nlm.nih.gov/pubmed/26433463
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