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Coadministration of lapatinib increases exposure to docetaxel but not doxorubicin in the small intestine of mice

Combination therapy is increasingly being utilized for the treatment of metastatic breast cancer. However, coadministration of drugs, particularly agents that are substrates for or inhibitors of p-glycoprotein, can result in increased tissue toxicity. Unfortunately, determination of levels of chemot...

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Publicat a:Anticancer Drugs
Autors principals: Hudachek, Susan F., Gustafson, Daniel L.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694043/
https://ncbi.nlm.nih.gov/pubmed/23928571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CAD.0b013e3283645e1a
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