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Cleavage of Signal Regulatory Protein α (SIRPα) Enhances Inflammatory Signaling

Signal regulatory protein α (SIRPα) is a membrane glycoprotein immunoreceptor abundant in cells of monocyte lineage. SIRPα ligation by a broadly expressed transmembrane protein, CD47, results in phosphorylation of the cytoplasmic immunoreceptor tyrosine-based inhibitory motifs, resulting in the inhi...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Londino, James D., Gulick, Dexter, Isenberg, Jeffrey S., Mallampalli, Rama K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692235/
https://ncbi.nlm.nih.gov/pubmed/26534964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.682914
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