Surfactant Protein D (Sp-D) Binds to Membrane-proximal Domain (D3) of Signal Regulatory Protein α (SIRPα), a Site Distant from Binding Domain of CD47, while Also Binding to Analogous Region on Signal Regulatory Protein β (SIRPβ)

Signal regulatory protein α (SIRPα), a highly glycosylated type-1 transmembrane protein, is composed of three immunoglobulin-like extracellular loops as well as a cytoplasmic tail containing three classical tyrosine-based inhibitory motifs. Previous reports indicate that SIRPα binds to humoral patte...

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Detalhes bibliográficos
Main Authors: Fournier, Bénédicte, Andargachew, Rakieb, Robin, Alexander Z., Laur, Oskar, Voelker, Dennis R., Lee, Winston Y., Weber, Dominique, Parkos, Charles A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365977/
https://ncbi.nlm.nih.gov/pubmed/22511785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.324533
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