The Redox State Regulates the Conformation of Rv2466c to Activate the Antitubercular Prodrug TP053

Rv2466c is a key oxidoreductase that mediates the reductive activation of TP053, a thienopyrimidine derivative that kills replicating and non-replicating Mycobacterium tuberculosis, but whose mode of action remains enigmatic. Rv2466c is a homodimer in which each subunit displays a modular architectu...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Albesa-Jové, David, Comino, Natalia, Tersa, Montse, Mohorko, Elisabeth, Urresti, Saioa, Dainese, Elisa, Chiarelli, Laurent R., Pasca, Maria Rosalia, Manganelli, Riccardo, Makarov, Vadim, Riccardi, Giovanna, Svergun, Dmitri I., Glockshuber, Rudi, Guerin, Marcelo E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692232/
https://ncbi.nlm.nih.gov/pubmed/26546681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.677039
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