The antibacterial prodrug activator Rv2466c is a mycothiol-dependent reductase in the oxidative stress response of Mycobacterium tuberculosis

The Mycobacterium tuberculosis rv2466c gene encodes an oxidoreductase enzyme annotated as DsbA. It has a CPWC active-site motif embedded within its thioredoxin fold domain and mediates the activation of the prodrug TP053, a thienopyrimidine derivative that kills both replicating and nonreplicating b...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Rosado, Leonardo Astolfi, Wahni, Khadija, Degiacomi, Giulia, Pedre, Brandán, Young, David, de la Rubia, Alfonso G., Boldrin, Francesca, Martens, Edo, Marcos-Pascual, Laura, Sancho-Vaello, Enea, Albesa-Jové, David, Provvedi, Roberta, Martin, Charlotte, Makarov, Vadim, Versées, Wim, Verniest, Guido, Guerin, Marcelo E., Mateos, Luis M., Manganelli, Riccardo, Messens, Joris
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555174/
https://ncbi.nlm.nih.gov/pubmed/28620052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.797837
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