Dose Frequency Ranging Pharmacokinetic Study of Tenofovir-Emtricitabine After Directly Observed Dosing in Healthy Volunteers to Establish Adherence Benchmarks (HPTN 066)

Oral preexposure prophylaxis (PrEP) trials report disparate efficacy attributed to variable adherence. HPTN 066 was conducted to establish objective, quantitative benchmarks for discrete, regular levels of adherence using directly observed dosing of tenofovir (TFV) disoproxil fumarate (TDF)/emtricit...

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Detalhes bibliográficos
Publicado no:AIDS Res Hum Retroviruses
Main Authors: Hendrix, Craig W., Andrade, Adriana, Bumpus, Namandjé N., Kashuba, Angela D., Marzinke, Mark A., Moore, Ayana, Anderson, Peter L., Bushman, Lane R., Fuchs, Edward J., Wiggins, Ilene, Radebaugh, Christine, Prince, Heather A., Bakshi, Rahul P., Wang, Ruili, Richardson, Paul, Shieh, Eugenie, McKinstry, Laura, Li, Xin, Donnell, Deborah, Elharrar, Vanessa, Mayer, Kenneth H., Patterson, Kristine B.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2016
Assuntos:
HIV Prevention
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692123/
https://ncbi.nlm.nih.gov/pubmed/26414912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2015.0182
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