Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks

Elf5 is a transcription factor with pivotal roles in the trophoblast compartment, where it reinforces a trophoblast stem cell (TSC)-specific transcriptional circuit. However, Elf5 is also present in differentiating trophoblast cells that have ceased to express other TSC genes such as Cdx2 and Eomes....

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Latos, Paulina A., Sienerth, Arnold R., Murray, Alexander, Senner, Claire E., Muto, Masanaga, Ikawa, Masahito, Oxley, David, Burge, Sarah, Cox, Brian J., Hemberger, Myriam
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691948/
https://ncbi.nlm.nih.gov/pubmed/26584622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.268821.115
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