An active site rearrangement within the Tetrahymena group I ribozyme releases nonproductive interactions and allows formation of catalytic interactions

Biological catalysis hinges on the precise structural integrity of an active site that binds and transforms its substrates and meeting this requirement presents a unique challenge for RNA enzymes. Functional RNAs, including ribozymes, fold into their active conformations within rugged energy landsca...

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Detalhes bibliográficos
Publicado no:RNA
Main Authors: Sengupta, Raghuvir N., Van Schie, Sabine N.S., Giambaşu, George, Dai, Qing, Yesselman, Joseph D., York, Darrin, Piccirilli, Joseph A., Herschlag, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691833/
https://ncbi.nlm.nih.gov/pubmed/26567314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.053710.115
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