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A Rearrangement of the Guanosine-Binding Site Establishes an Extended Network of Functional Interactions in the Tetrahymena Group I Ribozyme Active Site

Protein enzymes appear to use extensive packing and hydrogen-bonding interactions to precisely position catalytic groups within active sites. Due to their inherent backbone flexibility and limited side chain repertoire, RNA enzymes face additional challenges relative to proteins in precisely positio...

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Bibliografiske detaljer
Main Authors: Forconi, Marcello, Sengupta, Raghuvir N., Piccirilli, Joseph A., Herschlag, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860537/
https://ncbi.nlm.nih.gov/pubmed/20175542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902200n
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