MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

The TOR (target of rapamycin) kinase limits longevity by poorly understood mechanisms. Rapamycin suppresses the mammalian TORC1 complex, which regulates translation, and extends lifespan in diverse species, including mice. We show that rapamycin selectively blunts the pro-inflammatory phenotype of s...

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Bibliografske podrobnosti
izdano v:Nat Cell Biol
Main Authors: Laberge, Remi-Martin, Sun, Yu, Orjalo, Arturo V., Patil, Christopher K., Freund, Adam, Zhou, Lili, Curran, Samuel C., Davalos, Albert R., Wilson-Edell, Kathleen A., Liu, Su, Limbad, Chandani, Demaria, Marco, Li, Patrick, Hubbard, Gene B., Ikeno, Yuji, Javors, Martin, Desprez, Pierre-Yves, Benz, Christopher C., Kapahi, Pankaj, Nelson, Peter S., Campisi, Judith
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691706/
https://ncbi.nlm.nih.gov/pubmed/26147250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3195
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