Genetic and epigenetic variation, but not diet, shape the sperm methylome

Paternal diet can impact metabolic phenotypes in offspring, but mechanisms underlying such intergenerational information transfer remain obscure. Here, we interrogate cytosine methylation patterns in sperm obtained from mice consuming one of three diets, generating whole genome methylation maps for...

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Bibliografiset tiedot
Julkaisussa:Dev Cell
Päätekijät: Shea, Jeremy M., Serra, Ryan W., Carone, Benjamin R., Shulha, Hennady P., Kucukural, Alper, Ziller, Michael J., Vallaster, Markus P., Gu, Hongcang, Tapper, Andrew R., Gardner, Paul D., Meissner, Alexander, Garber, Manuel, Rando, Oliver J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691283/
https://ncbi.nlm.nih.gov/pubmed/26702833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.11.024
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