Genetic and epigenetic variation, but not diet, shape the sperm methylome

Paternal diet can impact metabolic phenotypes in offspring, but mechanisms underlying such intergenerational information transfer remain obscure. Here, we interrogate cytosine methylation patterns in sperm obtained from mice consuming one of three diets, generating whole genome methylation maps for...

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Bibliografiske detaljer
Udgivet i:	Dev Cell
Main Authors:	Shea, Jeremy M., Serra, Ryan W., Carone, Benjamin R., Shulha, Hennady P., Kucukural, Alper, Ziller, Michael J., Vallaster, Markus P., Gu, Hongcang, Tapper, Andrew R., Gardner, Paul D., Meissner, Alexander, Garber, Manuel, Rando, Oliver J.
Format:	Artigo
Sprog:	Inglês
Udgivet:	2015
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4691283/ https://ncbi.nlm.nih.gov/pubmed/26702833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.11.024
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Genetic and epigenetic variation, but not diet, shape the sperm methylome

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