Genetic and epigenetic variation, but not diet, shape the sperm methylome

Paternal diet can impact metabolic phenotypes in offspring, but mechanisms underlying such intergenerational information transfer remain obscure. Here, we interrogate cytosine methylation patterns in sperm obtained from mice consuming one of three diets, generating whole genome methylation maps for...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Shea, Jeremy M., Serra, Ryan W., Carone, Benjamin R., Shulha, Hennady P., Kucukural, Alper, Ziller, Michael J., Vallaster, Markus P., Gu, Hongcang, Tapper, Andrew R., Gardner, Paul D., Meissner, Alexander, Garber, Manuel, Rando, Oliver J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691283/
https://ncbi.nlm.nih.gov/pubmed/26702833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.11.024
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