Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

Several recent studies link parental environments to phenotypes in subsequent generations. Here, we investigate the mechanism by which paternal diet affects offspring metabolism. Protein restriction in mice affects small RNA levels in mature sperm, with decreased let-7 levels and increased levels of...

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書誌詳細
出版年:Science
主要な著者: Sharma, Upasna, Conine, Colin C., Shea, Jeremy M., Boskovic, Ana, Derr, Alan G., Bing, Xin Y., Belleannee, Clemence, Kucukural, Alper, Serra, Ryan W., Sun, Fengyun, Song, Lina, Carone, Benjamin R., Ricci, Emiliano P., Li, Xin Z., Fauquier, Lucas, Moore, Melissa J., Sullivan, Robert, Mello, Craig C., Garber, Manuel, Rando, Oliver J.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888079/
https://ncbi.nlm.nih.gov/pubmed/26721685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad6780
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