High-resolution analyses of human sperm dynamic methylome reveal thousands of novel age-related epigenetic alterations

BACKGROUND: Children of aged fathers are at a higher risk of developing mental disorders. Alterations in sperm DNA methylation have been implicated as a potential cause. However, age-dependent modifications of the germ cells’ epigenome remain poorly understood. Our objective was to assess the DNA me...

Full description

Saved in:
Bibliographic Details
Published in:Clin Epigenetics
Main Authors: Cao, Mingju, Shao, Xiaojian, Chan, Peter, Cheung, Warren, Kwan, Tony, Pastinen, Tomi, Robaire, Bernard
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7735420/
https://ncbi.nlm.nih.gov/pubmed/33317634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-020-00988-1
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items