Dissecting features of epigenetic variants underlying cardiometabolic risk using full-resolution epigenome profiling in regulatory elements

Sparse profiling of CpG methylation in blood by microarrays has identified epigenetic links to common diseases. Here we apply methylC-capture sequencing (MCC-Seq) in a clinical population of ~200 adipose tissue and matched blood samples (N(total)~400), providing high-resolution methylation profiling...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Allum, Fiona, Hedman, Åsa K., Shao, Xiaojian, Cheung, Warren A., Vijay, Jinchu, Guénard, Frédéric, Kwan, Tony, Simon, Marie-Michelle, Ge, Bing, Moura, Cristiano, Boulier, Elodie, Rönnblom, Lars, Bernatsky, Sasha, Lathrop, Mark, McCarthy, Mark I., Deloukas, Panos, Tchernof, André, Pastinen, Tomi, Vohl, Marie-Claude, Grundberg, Elin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418220/
https://ncbi.nlm.nih.gov/pubmed/30872577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09184-z
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