14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common known cause of inherited Parkinson's disease (PD), and LRRK2 is a risk factor for idiopathic PD. How LRRK2 function is regulated is not well understood. Recently, the highly conserved 14-3-3 proteins, which play a key role in...

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Publicat a:Hum Mol Genet
Autors principals: Lavalley, Nicholas J., Slone, Sunny R., Ding, Huiping, West, Andrew B., Yacoubian, Talene A.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4690493/
https://ncbi.nlm.nih.gov/pubmed/26546614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv453
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