GRK2 Compromises Cardiomyocyte Mitochondrial Function by Diminishing Fatty Acid-Mediated Oxygen Consumption and Increasing Superoxide Levels

The G protein-coupled receptor kinase-2 (GRK2) is upregulated in the injured heart and contributes to heart failure pathogenesis. GRK2 was recently shown to associate with mitochondria but its functional impact in myocytes due to this localization is unclear. This study was undertaken to determine t...

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Publicat a:J Mol Cell Cardiol
Autors principals: Sato, Priscila Y, Chuprun, J Kurt, Ibetti, Jessica, Cannavo, Alessandro, Drosatos, Konstantinos, Elrod, John W, Koch, Walter J
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689631/
https://ncbi.nlm.nih.gov/pubmed/26506135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.10.002
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