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Enrollment and stopping rules for managing toxicity requiring long follow-up in Phase II oncology trials

Monitoring of toxicity is often conducted in Phase II trials in oncology to avoid an excessive number of toxicities if the wrong dose is chosen for Phase II. Existing stopping rules for toxicity use information from patients who have already completed follow-up. We describe a stopping rule that uses...

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Detalhes bibliográficos
Publicado no:J Biopharm Stat
Main Authors: Song, Guochen, Ivanova, Anastasia
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689581/
https://ncbi.nlm.nih.gov/pubmed/26383917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543406.2015.1086779
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