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Stopping rules employing response rates, time to progression, and early progressive disease for phase II oncology trials

BACKGROUND: Response rate (RR), the most common early means of assessing oncology drugs, is not suitable as the sole endpoint for phase II trials of drugs which induce disease stability but not regression. Time to progression (TTP) may be more sensitive to such agents, but induces recruitment delays...

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Détails bibliographiques
Auteurs principaux: Goffin, John R, Pond, Greg R
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259049/
https://ncbi.nlm.nih.gov/pubmed/22151297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2288-11-164
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