Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome

SCYX-7158, an oxaborole, is currently in Phase I clinical trials for the treatment of human African trypanosomiasis. Here we investigate possible modes of action against Trypanosoma brucei using orthogonal chemo-proteomic and genomic approaches. SILAC-based proteomic studies using an oxaborole analo...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Jones, Deuan C., Foth, Bernardo J., Urbaniak, Michael D., Patterson, Stephen, Ong, Han B., Berriman, Matthew, Fairlamb, Alan H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689576/
https://ncbi.nlm.nih.gov/pubmed/26684831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004299
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