Revealing Different Roles of the mTOR-Targets S6K1 and S6K2 in Breast Cancer by Expression Profiling and Structural Analysis

BACKGROUND: The AKT/mTORC1/S6K pathway is frequently overstimulated in breast cancer, constituting a promising therapeutic target. The benefit from mTOR inhibitors varies, likely as a consequence of tumour heterogeneity, and upregulation of several compensatory feed-back mechanisms. The mTORC1 downs...

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Udgivet i:PLoS One
Main Authors: Karlsson, Elin, Magić, Ivana, Bostner, Josefine, Dyrager, Christine, Lysholm, Fredrik, Hallbeck, Anna-Lotta, Stål, Olle, Lundström, Patrik
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689523/
https://ncbi.nlm.nih.gov/pubmed/26698305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145013
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