Activation of Akt, mTOR, and the estrogen receptor as a signature to predict tamoxifen treatment benefit

The frequent alterations of the PI3K/Akt/mTOR-growth signaling pathway are proposed mechanisms for resistance to endocrine therapy in breast cancer, partly through regulation of estrogen receptor α (ER) activity. Reliable biomarkers for treatment prediction are required for improved individualized t...

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Detalhes bibliográficos
Main Authors: Bostner, Josefine, Karlsson, Elin, Pandiyan, Muneeswaran J., Westman, Hanna, Skoog, Lambert, Fornander, Tommy, Nordenskjöld, Bo, Stål, Olle
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2012
Assuntos:
Preclinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539073/
https://ncbi.nlm.nih.gov/pubmed/23242584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-012-2376-y
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