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Activation of Akt, mTOR, and the estrogen receptor as a signature to predict tamoxifen treatment benefit
The frequent alterations of the PI3K/Akt/mTOR-growth signaling pathway are proposed mechanisms for resistance to endocrine therapy in breast cancer, partly through regulation of estrogen receptor α (ER) activity. Reliable biomarkers for treatment prediction are required for improved individualized t...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Springer US
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3539073/ https://ncbi.nlm.nih.gov/pubmed/23242584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-012-2376-y |
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