The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer: a retrospective study including patients from the randomised Stockholm tamoxifen trials

INTRODUCTION: mTOR and its downstream effectors the 4E-binding protein 1 (4EBP1) and the p70 ribosomal S6 kinases (S6K1 and S6K2) are frequently upregulated in breast cancer, and assumed to be driving forces in tumourigenesis, in close connection with oestrogen receptor (ER) networks. Here, we inves...

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Hauptverfasser: Karlsson, Elin, Pérez-Tenorio, Gizeh, Amin, Risul, Bostner, Josefine, Skoog, Lambert, Fornander, Tommy, Sgroi, Dennis C, Nordenskjöld, Bo, Hallbeck, Anna-Lotta, Stål, Olle
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978839/
https://ncbi.nlm.nih.gov/pubmed/24131622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3557
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