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Structure of the guide-strand-containing argonaute silencing complex
The slicer activity of the RNA-induced silencing complex is associated with argonaute, the RNase H-like PIWI domain of which catalyses guide-strand-mediated sequence-specific cleavage of target messenger RNA. Here we report on the crystal structure of Thermus thermophilus argonaute bound to a 5′-pho...
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| Udgivet i: | Nature |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4689319/ https://ncbi.nlm.nih.gov/pubmed/18754009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07315 |
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