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Nucleation, propagation and cleavage of target RNAs in argonaute silencing complexes
The slicer activity of the RNA-induced silencing complex resides within its Argonaute (Ago) component, whose PIWI domain provides the catalytic residues governing guide-strand mediated site-specific cleavage of target RNA. We report on structures of ternary complexes of T. thermophilus Ago catalytic...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2880917/ https://ncbi.nlm.nih.gov/pubmed/19812667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08434 |
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