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Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex
Here we report on a 3.0 Å crystal structure of a ternary complex of wild-type Thermus thermophilus argonaute bound to a 5′-phosphorylated 21-nucleotide guide DNA and a 20-nucleotide target RNA containing cleavage-preventing mismatches at the 10–11 step. The seed segment (positions 2 to 8) adopts an...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2765400/ https://ncbi.nlm.nih.gov/pubmed/19092929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07666 |
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