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Ligand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design
BACKGROUND: Cytochrome P450 sterol 14α-demethylase (CYP51) is an essential enzyme for sterol biosynthesis and a target for anti-parasitic drug design. However, the design of parasite-specific drugs that inhibit parasitic CYP51 without severe side effects remains challenging. The active site of CYP51...
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| Veröffentlicht in: | Biochim Biophys Acta |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4689311/ https://ncbi.nlm.nih.gov/pubmed/26493722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2015.10.015 |
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