Antitrypanosomal lead discovery: Identification of a ligand-efficient inhibitor of Trypanosoma cruzi CYP51 and parasite growth

Chagas disease is caused by the intracellular protozoan parasite Trypanosomal cruzi, and current drugs are lacking in terms of desired safety and efficacy profiles. Following on a recently reported high-throughput screening campaign, we have explored initial structure-activity relationships around a...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Andriani, Grasiella, Amata, Emanuele, Beatty, Joel, Clements, Zeke, Coffey, Brian J., Courtemanche, Gilles, Devine, William, Erath, Jessey, Juda, Cristin E., Wawrzak, Zdzislaw, Wood, JodiAnne T., Lepesheva, Galina I., Rodriguez, Ana, Pollastri, Michael P.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612894/
https://ncbi.nlm.nih.gov/pubmed/23448316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400012e
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker