Antitrypanosomal lead discovery: Identification of a ligand-efficient inhibitor of Trypanosoma cruzi CYP51 and parasite growth

Chagas disease is caused by the intracellular protozoan parasite Trypanosomal cruzi, and current drugs are lacking in terms of desired safety and efficacy profiles. Following on a recently reported high-throughput screening campaign, we have explored initial structure-activity relationships around a...

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Detalhes bibliográficos
Main Authors: Andriani, Grasiella, Amata, Emanuele, Beatty, Joel, Clements, Zeke, Coffey, Brian J., Courtemanche, Gilles, Devine, William, Erath, Jessey, Juda, Cristin E., Wawrzak, Zdzislaw, Wood, JodiAnne T., Lepesheva, Galina I., Rodriguez, Ana, Pollastri, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612894/
https://ncbi.nlm.nih.gov/pubmed/23448316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400012e
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