Crystal Structure of A. aeolicus Argonaute, a Site-Specific DNA-Guided Endoribonuclease, Provides Insights into RISC-Mediated mRNA Cleavage

Argonaute (Ago) proteins constitute a key component of the RNA-induced silencing complex (RISC). We report the crystal structure of Aquifex aeolicus Ago (Aa-Ago) together with binding and cleavage studies, which establish this eubacterial Ago as a bona fide guide DNA strand-mediated site-specific RN...

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Publicado no:Mol Cell
Main Authors: Yuan, Yu-Ren, Pei, Yi, Ma, Jin-Biao, Kuryavyi, Vitaly, Zhadina, Maria, Meister, Gunter, Chen, Hong-Ying, Dauter, Zbigniew, Tuschl, Thomas, Patel, Dinshaw J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689305/
https://ncbi.nlm.nih.gov/pubmed/16061186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2005.07.011
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