Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in novel piperaquine in vitro assays: retrospective and prospective investigations

BACKGROUND: The declining efficacy of dihydroartemisinin-piperaquine against Plasmodium falciparum in Cambodia, along with increasing numbers of recrudescent cases, suggests resistance to both artemisinin and piperaquine. Available in vitro piperaquine susceptibility assays do not correlate with tre...

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Bibliografske podrobnosti
izdano v:BMC Med
Main Authors: Duru, Valentine, Khim, Nimol, Leang, Rithea, Kim, Saorin, Domergue, Anais, Kloeung, Nimol, Ke, Sopheakvatey, Chy, Sophy, Eam, Rotha, Khean, Chanra, Loch, Kaknika, Ken, Malen, Lek, Dysoley, Beghain, Johann, Ariey, Frédéric, Guerin, Philippe J., Huy, Rekol, Mercereau-Puijalon, Odile, Witkowski, Benoit, Menard, Didier
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4688949/
https://ncbi.nlm.nih.gov/pubmed/26695060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12916-015-0539-5
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