Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in novel piperaquine in vitro assays: retrospective and prospective investigations

BACKGROUND: The declining efficacy of dihydroartemisinin-piperaquine against Plasmodium falciparum in Cambodia, along with increasing numbers of recrudescent cases, suggests resistance to both artemisinin and piperaquine. Available in vitro piperaquine susceptibility assays do not correlate with tre...

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Publicado no:BMC Med
Main Authors: Duru, Valentine, Khim, Nimol, Leang, Rithea, Kim, Saorin, Domergue, Anais, Kloeung, Nimol, Ke, Sopheakvatey, Chy, Sophy, Eam, Rotha, Khean, Chanra, Loch, Kaknika, Ken, Malen, Lek, Dysoley, Beghain, Johann, Ariey, Frédéric, Guerin, Philippe J., Huy, Rekol, Mercereau-Puijalon, Odile, Witkowski, Benoit, Menard, Didier
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4688949/
https://ncbi.nlm.nih.gov/pubmed/26695060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12916-015-0539-5
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