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Role of the mammalian target of rapamycin pathway and rapamycin in lentiviral vector gene transduction of hematopoietic stem cells

PURPOSE OF REVIEW: A major goal in repopulating hematopoietic stem cell (HSC) gene therapies is achieving high-efficacy gene transfer, while maintaining robust HSC engraftment and differentiation in vivo. Recent studies have documented that rapamycin treatment of HSC during lentiviral vector transdu...

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Bibliografske podrobnosti
izdano v:Curr Opin Hematol
Main Authors: Wang, Cathy X., Torbett, Bruce E.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4688901/
https://ncbi.nlm.nih.gov/pubmed/26049750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MOH.0000000000000150
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