Flunarizine prevents hepatitis C virus membrane fusion in a genotype‐dependent manner by targeting the potential fusion peptide within E1

To explore mechanisms of hepatitis C viral (HCV) replication we screened a compound library including licensed drugs. Flunarizine, a diphenylmethylpiperazine used to treat migraine, inhibited HCV cell entry in vitro and in vivo in a genotype‐dependent fashion. Analysis of mosaic viruses between susc...

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發表在:Hepatology
Main Authors: Perin, Paula M., Haid, Sibylle, Brown, Richard J.P., Doerrbecker, Juliane, Schulze, Kai, Zeilinger, Carsten, von Schaewen, Markus, Heller, Brigitte, Vercauteren, Koen, Luxenburger, Eva, Baktash, Yasmine M., Vondran, Florian W.R., Speerstra, Sietkse, Awadh, Abdullah, Mukhtarov, Furkat, Schang, Luis M., Kirschning, Andreas, Müller, Rolf, Guzman, Carlos A., Kaderali, Lars, Randall, Glenn, Meuleman, Philip, Ploss, Alexander, Pietschmann, Thomas
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2015
主題:
Viral Hepatitis
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4688136/
https://ncbi.nlm.nih.gov/pubmed/26248546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28111
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