Flunarizine prevents hepatitis C virus membrane fusion in a genotype‐dependent manner by targeting the potential fusion peptide within E1

To explore mechanisms of hepatitis C viral (HCV) replication we screened a compound library including licensed drugs. Flunarizine, a diphenylmethylpiperazine used to treat migraine, inhibited HCV cell entry in vitro and in vivo in a genotype‐dependent fashion. Analysis of mosaic viruses between susc...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Perin, Paula M., Haid, Sibylle, Brown, Richard J.P., Doerrbecker, Juliane, Schulze, Kai, Zeilinger, Carsten, von Schaewen, Markus, Heller, Brigitte, Vercauteren, Koen, Luxenburger, Eva, Baktash, Yasmine M., Vondran, Florian W.R., Speerstra, Sietkse, Awadh, Abdullah, Mukhtarov, Furkat, Schang, Luis M., Kirschning, Andreas, Müller, Rolf, Guzman, Carlos A., Kaderali, Lars, Randall, Glenn, Meuleman, Philip, Ploss, Alexander, Pietschmann, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Viral Hepatitis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4688136/
https://ncbi.nlm.nih.gov/pubmed/26248546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28111
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