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Role of protein dynamics in ion selectivity and allosteric coupling in the NaK channel

Flux-dependent inactivation that arises from functional coupling between the inner gate and the selectivity filter is widespread in ion channels. The structural basis of this coupling has only been well characterized in KcsA. Here we present NMR data demonstrating structural and dynamic coupling bet...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Brettmann, Joshua B., Urusova, Darya, Tonelli, Marco, Silva, Jonathan R., Henzler-Wildman, Katherine A.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687598/
https://ncbi.nlm.nih.gov/pubmed/26621745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1515965112
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