Role of protein dynamics in ion selectivity and allosteric coupling in the NaK channel

Flux-dependent inactivation that arises from functional coupling between the inner gate and the selectivity filter is widespread in ion channels. The structural basis of this coupling has only been well characterized in KcsA. Here we present NMR data demonstrating structural and dynamic coupling bet...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Brettmann, Joshua B., Urusova, Darya, Tonelli, Marco, Silva, Jonathan R., Henzler-Wildman, Katherine A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687598/
https://ncbi.nlm.nih.gov/pubmed/26621745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1515965112
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