Type I interferons mediate pancreatic toxicities of PERK inhibition

The great preclinical promise of the pancreatic endoplasmic reticulum kinase (PERK) inhibitors in neurodegenerative disorders and cancers is marred by pancreatic injury and diabetic syndrome observed in PERK knockout mice and humans lacking PERK function and suffering from Wolcott-Rallison syndrome....

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Yu, Qiujing, Zhao, Bin, Gui, Jun, Katlinski, Kanstantsin V., Brice, Angela, Gao, Yan, Li, ChangHong, Kushner, Jake A., Koumenis, Constantinos, Diehl, J. Alan, Fuchs, Serge Y.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687574/
https://ncbi.nlm.nih.gov/pubmed/26627716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516362112
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