Type I interferons mediate pancreatic toxicities of PERK inhibition

The great preclinical promise of the pancreatic endoplasmic reticulum kinase (PERK) inhibitors in neurodegenerative disorders and cancers is marred by pancreatic injury and diabetic syndrome observed in PERK knockout mice and humans lacking PERK function and suffering from Wolcott-Rallison syndrome....

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Yu, Qiujing, Zhao, Bin, Gui, Jun, Katlinski, Kanstantsin V., Brice, Angela, Gao, Yan, Li, ChangHong, Kushner, Jake A., Koumenis, Constantinos, Diehl, J. Alan, Fuchs, Serge Y.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687574/
https://ncbi.nlm.nih.gov/pubmed/26627716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516362112
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