Suppression of type I interferon signaling overcomes oncogene-induced senescence and mediates melanoma development and progression

Oncogene activation induces DNA damage responses and cell senescence. We report a key role of type I interferons (IFN) in oncogene-induced senescence. IFN signaling-deficient melanocytes expressing activated Braf do not exhibit senescence and develop aggressive melanomas. Restoration of IFN signalin...

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Publicado no:Cell Rep
Main Authors: Katlinskaya, Yuliya V., Katlinski, Kanstantsin V., Yu, Qiujing, Ortiz, Angelica, Beiting, Daniel P., Brice, Angela, Davar, Diwakar, Sanders, Cindy, Kirkwood, John M., Rui, Hallgeir, Xu, Xiaowei, Koumenis, Constantinos, Diehl, J. Alan, Fuchs, Serge Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826807/
https://ncbi.nlm.nih.gov/pubmed/27052162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.03.006
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