Suppression of type I interferon signaling overcomes oncogene-induced senescence and mediates melanoma development and progression

Oncogene activation induces DNA damage responses and cell senescence. We report a key role of type I interferons (IFN) in oncogene-induced senescence. IFN signaling-deficient melanocytes expressing activated Braf do not exhibit senescence and develop aggressive melanomas. Restoration of IFN signalin...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell Rep
Päätekijät: Katlinskaya, Yuliya V., Katlinski, Kanstantsin V., Yu, Qiujing, Ortiz, Angelica, Beiting, Daniel P., Brice, Angela, Davar, Diwakar, Sanders, Cindy, Kirkwood, John M., Rui, Hallgeir, Xu, Xiaowei, Koumenis, Constantinos, Diehl, J. Alan, Fuchs, Serge Y.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826807/
https://ncbi.nlm.nih.gov/pubmed/27052162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.03.006
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